Piperazine → HCID 19428528, compound

HRID 1078966Notes

Reaction equation

HRID 1078966 reaction equation
[CH2:1]1[CH2:27][O:26][C:3]2([CH2:8][CH2:7][N:6]([C:9]3[CH:14]=[C:13]([N:15]4[CH2:20][CH2:19][C:18]5([O:24][CH2:23][CH2:22][O:21]5)[CH2:17][CH2:16]4)[N:12]=[C:11](Cl)[N:10]=3)[CH2:5][CH2:4]2)[O:2]1.[NH:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[CH2:1]1[CH2:27][O:26][C:3]2([CH2:8][CH2:7][N:6]([C:9]3[CH:14]=[C:13]([N:15]4[CH2:20][CH2:19][C:18]5([O:24][CH2:23][CH2:22][O:21]5)[CH2:17][CH2:16]4)[N:12]=[C:11]([N:28]4[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]4)[N:10]=3)[CH2:5][CH2:4]2)[O:2]1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 19428530HCID 19428530, compound

Product 1

HCID 19428528HCID 19428528, compoundYield 58.9%

Procedure

The reaction of 4,6-bis(4,4-ethylenedioxy-1-piperidinyl)-2-chloropyrimidine with piperazine as described in Example 4 gives the title compound in a yield of 58.9%, m.p.: 122°-126° C.

Sources & evidence

ORD record
ord-5bb3ca1c97b4447a98e330b94175f2bb
Source dataset
uspto-grants-1996_08
Patent number
US05550240

Reaction notes

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