反应详情

A mixture of cyclopentylacetic acid (10.02 g, 8.2 mmol), benzyl alcohol (8.45 g, 78.2 mmol) and p-toluenesulfonic acid monohydrate (1.48 g, 7.82 mmol) in benzene (60 mL) was refluxed using a Dean-Stark water separator for 2 h. After cooling, benzene was removed and the mixture was diluted with ether (50 mL) and washed successively with saturated NaHCO3 solution, saturated brine solution, dried and evaporated to give the compound (15.40 g) as an oil;

1. temperaturewas refluxed
2. temperatureAfter cooling
3. custombenzene was removed
4. additionthe mixture was diluted with ether (50 mL)
5. washwashed successively with saturated NaHCO3 solution, saturated brine solution
6. customdried
7. customevaporated