反应详情

Methanesulfonic acid (99%, 100 g, 1.0 mole) was added slowly to a stirred mixture of 5-amino-2-chlorobenzoic acid (85%, 100 g, 0.5 mole) in 2-methylcyclohexanol (200 g, 1.85 mole). The mixture was heated under reflux with stirring for 6 hours, then the excess 2-methylcyclohexanol was evaporated under reduced pressure. The residue was then dissolved in methylene chloride (800 ml), washed with water (300 ml), 5% sodium bicarbonate solution (300 ml), water (300 ml), dried (magnesium sulfate), and filtered. The solvent was then evaporated to give 109 g of 2-methylcyclohexyl 5-amino-2-chlorobenzoate as a light brown oil.

1. temperatureThe mixture was heated
2. temperatureunder reflux
3. customthe excess 2-methylcyclohexanol was evaporated under reduced pressure
4. dissolutionThe residue was then dissolved in methylene chloride (800 ml)
5. washwashed with water (300 ml), 5% sodium bicarbonate solution (300 ml), water (300 ml)
6. dry with materialdried (magnesium sulfate)
7. filtrationfiltered
8. customThe solvent was then evaporated