Hydrochloric Acid → HCID 23366697, compound

HRID 1079327Notes

Reaction equation

HRID 1079327 reaction equation
[CH3:1][C:2]1[C:7]2[CH2:8][NH:9][CH2:10][CH2:11][S:12][C:6]=2[CH:5]=[CH:4][CH:3]=1.Cl.[C:14](OC(=O)C)(=[O:16])[CH3:15]>>[C:14]([N:9]1[CH2:8][C:7]2[C:2]([CH3:1])=[CH:3][CH:4]=[CH:5][C:6]=2[S:12][CH2:11][CH2:10]1)(=[O:16])[CH3:15]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 7918Acetic AnhydrideHCID 23366689HCID 23366689, compound

Product 1

HCID 23366697HCID 23366697, compound

Procedure

A solution of 6-methyl-2,3,4,5-tetrahydro-1,4-benzothiazepine (0.91 g, prepared in a similar manner to its hydrochloride, Example 4 above) in acetic anhydride (10 ml) was stirred at room temperature for one hour. The reaction mixture was poured into ice and extracted with dichloromethane. The organic layer was dried and the solvent removed by evaporation to give 4-acetyl-6-methyl-2,3,4,5-tetrahydro-1,4-benzothiazepine, which was recrystallised from hexane. Yield 0.93 g (m.p. 71°-73° C.).

Workup

  1. additionThe reaction mixture was poured into ice
  2. extractionextracted with dichloromethane
  3. customThe organic layer was dried
  4. customthe solvent removed by evaporation

Sources & evidence

ORD record
ord-1457bc54ab8c4a8f9f2cf532498aeb8a
Source dataset
uspto-grants-1996_12
Patent number
US05580866

Reaction notes

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