2-Aminoquinoline → HCID 23366751, compound

HRID 1079352Notes

Reaction equation

HRID 1079352 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.Cl[C:13]1[C:22]2[C:17](=[CH:18][C:19]([O:25][CH3:26])=[C:20]([O:23][CH3:24])[CH:21]=2)[N:16]=[CH:15][N:14]=1>>[CH3:24][O:23][C:20]1[CH:21]=[C:22]2[C:17](=[CH:18][C:19]=1[O:25][CH3:26])[N:16]=[CH:15][N:14]=[C:13]2[NH:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 113792-AminoquinolineHCID 27693644-Chloro-6,7-dimethoxyquinazoline

Product 1

HCID 23366751HCID 23366751, compoundYield 56%

Procedure

Using an analogous procedure to that described in Example 9, 2-aminoquinoline was reacted with 4-chloro-6,7-dimethoxyquinazoline to give 6,7-dimethoxy-4-(2-quinolylamino)quinazoline in 56% yield, m.p. 215°-216° C.;

Sources & evidence

ORD record
ord-bd479ba964814ba7b49733990bff7f69
Source dataset
uspto-grants-1996_12
Patent number
US05580870

Reaction notes

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