HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1079384Generated: October 30, 2026
Potassium Iodide → 1-Acetyl-4-(4-morpholinophenyloxy)piperidine
https://huagongshe.com/reaction/1079384
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Bis(2-chloroethyl) ether | HCID 8115 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Acetyl-4-(4-aminophenyloxy) piperidine | HCID 15389156 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-Acetyl-4-(4-morpholinophenyloxy)piperidine | HCID 23366936 | — |
Reaction Steps
1-Acetyl-4-(4-aminophenyloxy)piperidine (1.77 g) obtained in Example 1 was dissolved in dimethylformamide (10 ml) and to the mixture were added potassium carbonate (2.1 g), potassium iodide (0.2 g) and 2,2'-dichloroethyl ether (0.9 ml), followed by heating with stirring at 100° C. overnight. The mixture was worked up according to the same manner as that described in Example 1 to obtain a colorless oily compound (1.4 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05580883 |
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| Source dataset | uspto-grants-1996_12 |
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| ORD ID | ord-59d19d13752b47e1a42eed73bd1b3a44 |
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| Source note | uspto-grants-1996_12 |
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