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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1079396Generated: October 30, 2026

1-Acetyl-4-[4-(piperidin-1-yl)phenylamino]piperidine dihydrochloride → 4-[4-(Piperidin-1-yl)phenylamino]piperidine trihydrochloride

https://huagongshe.com/reaction/1079396

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Acetyl-4-[4-(piperidin-1-yl)phenylamino]piperidine dihydrochlorideHCID 23366978—
SolventHydrochloric AcidHCID 313—
Product4-[4-(Piperidin-1-yl)phenylamino]piperidine trihydrochlorideHCID 23366926217.5%

Reaction Conditions

Temperature100 °C

Reaction Steps

A solution of 1-acetyl-4-[4-(piperidin-1-yl)phenylamino]piperidine dihydrochloride (0.70 g) in conc. hydrochloric acid (5 ml) was heated with stirring at 100° C. for 15 hours. After the solvent was distilled off, the residue was recrystallized from ethanol to obtain colorless crystals (0.5 g), m.p. 185°-189° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05580883
Source datasetuspto-grants-1996_12
ORD IDord-ef986928f4fb478d915690db26c14701
Source noteuspto-grants-1996_12