1-Acetyl-4-[4-(piperidin-1-yl)phenylamino]piperidine dihydrochloride → 4-[4-(Piperidin-1-yl)phenylamino]piperidine trihydrochloride

HRID 1079396Notes

Reaction equation

[ClH:1].Cl.C([N:6]1[CH2:11][CH2:10][CH:9]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([N:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)=[CH:15][CH:14]=2)[CH2:8][CH2:7]1)(=O)C>Cl>[ClH:1].[ClH:1].[ClH:1].[N:19]1([C:16]2[CH:15]=[CH:14][C:13]([NH:12][CH:9]3[CH2:10][CH2:11][NH:6][CH2:7][CH2:8]3)=[CH:18][CH:17]=2)[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]1

Participants

Conditions

Temperature: 100 °C

Procedure

A solution of 1-acetyl-4-[4-(piperidin-1-yl)phenylamino]piperidine dihydrochloride (0.70 g) in conc. hydrochloric acid (5 ml) was heated with stirring at 100° C. for 15 hours. After the solvent was distilled off, the residue was recrystallized from ethanol to obtain colorless crystals (0.5 g), m.p. 185°-189° C.

Workup

distillationAfter the solvent was distilled off
customthe residue was recrystallized from ethanol

Sources & evidence

ORD record: ord-ef986928f4fb478d915690db26c14701
Source dataset: uspto-grants-1996_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05580883

Reaction notes

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