Hydrochloric Acid → HCID 23366949, compound

Participants

Reaction Steps

To a solution of 1-Acetyl-4-(4-nitro-2methylphenyoxy)piperidine (4.5 g) obtained in Example 23, (1) in ethanol (70 ml) was added conc. hydrochloric acid (1.4 ml) and, by using 10% palladium/carbon (containing 48% water, 0.5 g) as a catalyst, catalytic reduction was conducted under normal pressure for 2 hours. The catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to obtain 1-acetyl-4-(4-amino-2methylphenyloxy)piperidine hydrochloride (5.1 g) as a light brown amorphous material.

Provenance & Evidence