Hydrochloric Acid → HCID 23366949, compound

HRID 1079407Notes

Reaction equation

HRID 1079407 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([O:10][C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][C:12]=2[CH3:20])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[ClH:21]>C(O)C.[Pd]>[ClH:21].[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([O:10][C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][C:12]=2[CH3:20])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 23366939HCID 23366939, compound

Product 1

HCID 23366949HCID 23366949, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of 1-Acetyl-4-(4-nitro-2methylphenyoxy)piperidine (4.5 g) obtained in Example 23, (1) in ethanol (70 ml) was added conc. hydrochloric acid (1.4 ml) and, by using 10% palladium/carbon (containing 48% water, 0.5 g) as a catalyst, catalytic reduction was conducted under normal pressure for 2 hours. The catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to obtain 1-acetyl-4-(4-amino-2methylphenyloxy)piperidine hydrochloride (5.1 g) as a light brown amorphous material.

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-2469c02ce61648adaecc862a57fcfaac
Source dataset
uspto-grants-1996_12
Patent number
US05580883

Reaction notes

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