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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 107945Generated: October 26, 2026

Methane → 5-Chloromethyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/107945

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethaneHCID 297—
ReactantChlorideHCID 312—
ReactantTetrahydrofuranHCID 8028—
ReactantTriethylamineHCID 8471—
ReactantEthyl AcetateHCID 8857—
ReactantTetrabutylammoniumHCID 16028—
ReactantSulfuryl chlorideHCID 24648—
Reactant1,1-Dimethylethyl 3,4-dihydro-5-(hydroxymethyl)-2(1H)-isoquinolinecarboxylateHCID 69561216—
Product5-Chloromethyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl esterHCID 20825952—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (2/10)
ORD IDord-ab5156f8d15146f1a20957e859647438
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (2/10)