Methane → 5-Chloromethyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester
Reaction equation
[C:14]([CH3:15])([CH3:16])([CH3:17])[O:18][C:19](=[O:20])[N:21]1[CH2:22][c:23]2[cH:24][cH:25][cH:26][c:27]([CH2:31][OH:32])[c:28]2[CH2:29][CH2:30]1.[CH2:39]([N+:40]([CH2:41][CH2:42][CH2:43][CH3:44])([CH2:45][CH2:46][CH2:47][CH3:48])[CH2:49][CH2:50][CH2:51][CH3:52])[CH2:53][CH2:54][CH3:55].[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH2:6][CH3:7].[CH3:56][CH2:57][O:58][C:59](=[O:60])[CH3:61].[CH4:13].[Cl-:38].[O:33]1[CH2:34][CH2:35][CH2:36][CH2:37]1.[S:8]([Cl:9])(=[O:10])([Cl:11])=[O:12]>>[Cl:11][CH2:31][c:27]1[cH:26][cH:25][cH:24][c:23]2[c:28]1[CH2:29][CH2:30][N:21]([C:19]([O:18][C:14]([CH3:15])([CH3:16])[CH3:17])=[O:20])[CH2:22]2Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-ab5156f8d15146f1a20957e859647438
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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