2-Bromoethanol → HCID 23367219, compound

To the mixture of 5-methylthiazole (10 g) and dioxane (20 ml) was added 2-bromoethanol (15 g), and the resulting mixture was heated under reflux for 4 hours. To the mixture left standing at room temperature for about 0.5 hour was added acetone (100 ml) with stirring to crystallize pale yellow solids. The supernatant was discarded, and acetone (50 ml) and ether (150 ml) were added with stirring to give white to pale yellow solids, which were collected by filtration, washed with ether and dried under reduced pressure.

1. temperaturethe resulting mixture was heated
2. temperatureunder reflux for 4 hours
3. waitTo the mixture left
4. customto crystallize pale yellow solids
5. additionacetone (50 ml) and ether (150 ml) were added
6. stirringwith stirring
7. customto give white to pale yellow solids, which
8. filtrationwere collected by filtration
9. washwashed with ether
10. customdried under reduced pressure

ORD record

ord-7bcc7018bf434a459f60332cfd421457

Source dataset

uspto-grants-1996_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05580904