反应详情

温度

45 °C

The product of Step 1 is dissolved in 200 mL of 2:1 THF:water and to this solution is added 6 mL of acetic acid. The reaction mixture is heated at 45° C. for approximately 5 hours. The THF is removed under reduced pressure and the aqueous reaction mixture is adjusted to a pH in the range of 8 to 9 with 10% sodium carbonate and is then extracted with methylene chloride. The organic layer is dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to afford the title compound.

1. customThe THF is removed under reduced pressure
2. extractionis then extracted with methylene chloride
3. dry with materialThe organic layer is dried over anhydrous sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated in vacuo