Sodium Carbonate → 3-[[2-(4-Morpholinyl)ethyl]amino]-1,2-benzisoxazol-6-ol

HRID 1080424Notes

Reaction equation

HRID 1080424 reaction equation
C[O:2][C:3]1[CH:20]=[CH:19][C:6]2[C:7]([NH:10][CH2:11][CH2:12][N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)=[N:8][O:9][C:5]=2[CH:4]=1.C(=O)([O-])[O-].[Na+].[Na+]>Br>[N:13]1([CH2:12][CH2:11][NH:10][C:7]2[C:6]3[CH:19]=[CH:20][C:3]([OH:2])=[CH:4][C:5]=3[O:9][N:8]=2)[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1

Participants

4

Reactant 2

HCID 10340Sodium CarbonateHCID 187964566-Methoxy-N-[2-(4-morpholinyl)ethyl]-1,2-benzisoxazol-3-amine

Product 1

HCID 1358150593-[[2-(4-Morpholinyl)ethyl]amino]-1,2-benzisoxazol-6-olYield 36.3%

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

6-Methoxy-N-[2-(4-morpholinyl)ethyl]-1,2-benzisoxazol-3-amine (2.9 g) was dissolved in 48% hydrobromic acid (50 ml) and heated to reflux under nitrogen for 3 hours. The reaction was cooled to room temperature, neutralized with saturated sodium carbonate (Na2CO3) solution, and extracted with EtOAc. The organic phase was dried over MgSO4 and concentrated in vacuo. Flash chromatography (silica gel) eluting with 3:2 acetone/heptane and subsequently titration with DCM/heptane provided the product (1.0 g), m.p. 151°-152° C.

Workup

  1. temperatureheated
  2. temperatureto reflux under nitrogen for 3 hours
  3. extractionextracted with EtOAc
  4. dry with materialThe organic phase was dried over MgSO4
  5. concentrationconcentrated in vacuo
  6. washFlash chromatography (silica gel) eluting with 3:2 acetone/heptane and subsequently titration with DCM/heptane

Sources & evidence

ORD record
ord-9df60feab8ee4eefa4b48a40c2518e96
Source dataset
uspto-grants-1996_12
Patent number
US05580982

Reaction notes

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