反应详情

0.526 g of methanesulfonyl chloride are added to a mixture of 1.8 g of the product obtained in step 4 and 0.46 g of triethylamine in 40 ml of dichloromethane. The reaction mixture is stirred at ambient temperature for 1h and is then concentrated under vacuum. The residue is taken up with ethyl acetate, washed with water, dried over Na2SO4 and concentrated under vacuum to give 2 g of the expected product.

1. concentrationis then concentrated under vacuum
2. washwashed with water
3. dry with materialdried over Na2SO4
4. concentrationconcentrated under vacuum