反应详情

A solution of 1.44 g of 2,6-dichloro-7-methylpurine, 1.63 g of 1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline hydrochloride and 1.5 g of triethylamine in 25 ml of methylene chloride was stirred at room temperature under nitrogen for 15 hours. The reaction mixture was washed with a 1N hydrochloric acid solution (3×150 ml), water (3×150 ml) and a brine solution (1×100 ml), and then dried over sodium sulfate. Removal of the solvent left a residue which was chromatographed on 150 g of silica gel, 1.3 g.

1. washThe reaction mixture was washed with a 1N hydrochloric acid solution (3×150 ml), water (3×150 ml)
2. dry with materiala brine solution (1×100 ml), and then dried over sodium sulfate
3. customRemoval of the solvent
4. waitleft a residue which
5. customwas chromatographed on 150 g of silica gel, 1.3 g