Methanol → HCID 252528, compound

HRID 1080707Notes

Reaction equation

HRID 1080707 reaction equation
[CH:1]([C:4]1[CH:14]=[CH:13][C:7]([CH:8]([OH:12])[C:9]([OH:11])=[O:10])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[CH3:15]O>>[CH:1]([C:4]1[CH:14]=[CH:13][C:7]([CH:8]([OH:12])[C:9]([O:11][CH3:15])=[O:10])=[CH:6][CH:5]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 887MethanolHCID 23423233Hydroxy(4-isopropylphenyl)acetic acid

Product 1

HCID 252528HCID 252528, compound

Procedure

To a solution of 4-isopropylmandelic acid (17 g) in methanol (150 ml) was added Dowex-50X-400® and the mixture was refluxed for 4 hours. After cooling it was filtered through Celite® and the filtrate was evaporated to give a syrupy residue of methyl 4-isopropylmandelate (18.9 g), which solidified upon storing at room temperature.

Workup

  1. temperaturethe mixture was refluxed for 4 hours
  2. temperatureAfter cooling it
  3. filtrationwas filtered through Celite®
  4. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-a4414e79a9e04c73b0e36da095dee9bb
Source dataset
uspto-grants-1996_12
Patent number
US05583147

Reaction notes

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