Methylamine → 1-(2-isopropyloxazol-4-yl)-N-methylmethanamine

HRID 1081153Notes

Reaction equation

HRID 1081153 reaction equation
[CH3:1][NH2:2].Cl[CH2:4][C:5]1[N:6]=[C:7]([CH:10]([CH3:12])[CH3:11])[O:8][CH:9]=1>O1CCOCC1.O>[CH:10]([C:7]1[O:8][CH:9]=[C:5]([CH2:4][NH:2][CH3:1])[N:6]=1)([CH3:12])[CH3:11]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 27632914-(Chloromethyl)-2-(propan-2-yl)-1,3-oxazole

Product 1

HCID 108207841-(2-isopropyloxazol-4-yl)-N-methylmethanamineYield 71%

Reagents, catalysts & solvents 1

HCID 218864351,4-Dioxane--water (1/1)Solvent

Procedure

To 40% aqueous methylamine (100 mL) was added dropwise a suspension of 4-chloromethyl-2-isopropyloxazole (4.20 g, 0.0263 mol) in p-dioxane/H2O (1:1 (v/v), 20 mL) over a 25 min period. After stirring for 45 min at ambient temperature, the volume was reduced to ca. 50 mL by rotary evaporation in vacuo, and NaCl was added. The aqueous was extracted with CHCl3 (4×100 mL), and the combined extract was dried over Na2SO4 and concentrated in vacuo. The resulting brown liquid was chromatographed on a 200 g SiO2 flash column with 2%/PrNH2 /CH2Cl2 followed by a gradient of /PrNH2 /MeOH/CH2Cl2 (0.5:2:97.5, 0.5:4:95.5). Concentration in vacuo of the product-containing fractions afforded the desired compound as a golden oil (2.89 g, 0.0187 mol, 71%): 1H NMR (CDCl3) δ1.33 (d, J=6.9 Hz, 6H), 2.46 (s, 3H), 2.99-3.14 (m, 1H), 3.64 (s, 2H), 7.42 (s, 1H). Mass spectrum: (M+H)+ =155, (M +NH4)+ =172.

Workup

  1. customthe volume was reduced to ca. 50 mL by rotary evaporation in vacuo, and NaCl
  2. additionwas added
  3. extractionThe aqueous was extracted with CHCl3 (4×100 mL)
  4. extractionthe combined extract
  5. dry with materialwas dried over Na2SO4
  6. concentrationconcentrated in vacuo
  7. customThe resulting brown liquid was chromatographed on a 200 g SiO2 flash column with 2%/PrNH2 /CH2Cl2
  8. concentrationConcentration in vacuo of the product-containing fractions

Sources & evidence

ORD record
ord-fbb940d90f2a4ac48c7e41b9b44a997e
Source dataset
uspto-grants-1996_12
Patent number
US05583232

Reaction notes

Loading…