Imidazole → HCID 86750068, compound

HRID 1081259Notes

Reaction equation

HRID 1081259 reaction equation
[CH3:1][C:2]1([CH3:25])[C:10]2([CH3:11])[CH:5]([C:6](=[O:12])[CH2:7][CH2:8][CH2:9]2)[CH2:4][CH:3]1[CH2:13][CH2:14][O:15][CH2:16][CH2:17][CH2:18][C:19]([CH2:23][CH3:24])([OH:22])[CH2:20][CH3:21].[CH3:26][Si:27]([CH3:30])([CH3:29])Cl.N1C=CN=C1.N1C=CC=CC=1>C(OCC)C>[CH3:25][C:2]1([CH3:1])[C:10]2([CH3:11])[CH:5]([C:6](=[O:12])[CH2:7][CH2:8][CH2:9]2)[CH2:4][CH:3]1[CH2:13][CH2:14][O:15][CH2:16][CH2:17][CH2:18][C:19]([CH2:23][CH3:24])([O:22][Si:27]([CH3:30])([CH3:29])[CH3:26])[CH2:20][CH3:21]

Participants

6

Reactant 4

HCID 795ImidazoleHCID 1049PyridineHCID 6397ChlorotrimethylsilaneHCID 86750066HCID 86750066, compound

Product 1

HCID 86750068HCID 86750068, compoundYield 80.6%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

183 mg (0.52 mmol) of 51 is reacted with 171 mg (1.56 mmol) of trimethylchlorosilane, 140 mg (2.03 mmol) of imidazole and 0.21 ml of pyridine in 15 ml of diethyl ether analogously to 33., and 178 mg of the title compound is obtained as colorless oil.

Sources & evidence

ORD record
ord-a8254b90657b4728812169f3ddcb42b5
Source dataset
uspto-grants-1996_12
Patent number
US05585368

Reaction notes

Loading…