HCID 10578293, compound → HCID 10459957, compound

HRID 1081315Notes

Reaction equation

HRID 1081315 reaction equation
[F:1][C:2]([F:38])([F:37])[C:3]1[CH:4]=[C:5]([CH:30]=[C:31]([C:33]([F:36])([F:35])[F:34])[CH:32]=1)[CH2:6][N:7]([CH3:29])[C:8]([C:10]1[N:19]([CH3:20])[C:18](=[O:21])[C:17]2[C:12](=[N:13][CH:14]=[CH:15][CH:16]=2)[C:11]=1[C:22]1[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=1)=[O:9]>CO.[Pd]>[F:37][C:2]([F:1])([F:38])[C:3]1[CH:4]=[C:5]([CH:30]=[C:31]([C:33]([F:35])([F:34])[F:36])[CH:32]=1)[CH2:6][N:7]([CH3:29])[C:8]([C:10]1[N:19]([CH3:20])[C:18](=[O:21])[C:17]2[CH2:16][CH2:15][CH2:14][NH:13][C:12]=2[C:11]=1[C:22]1[CH:23]=[CH:24][C:25]([F:28])=[CH:26][CH:27]=1)=[O:9]

Participants

4

Reactant 1

HCID 10578293HCID 10578293, compound

Product 1

HCID 10459957HCID 10459957, compoundYield 69.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

In methanol (8 ml) was dissolved N-[3,5-bis (trifluoromethyl)benzyl]-8-(4-fluorophenyl]-5,6-dihydro-N, 6-dimethyl-5-oxo-7-pyrido[4,3-b]pyridinecarboxamide (Example 19) (50 mg). To the solution was added 10% Pd-C (50% hydrous) (40 mg). The mixture was stirred for 3 hours at room temperature under hydrogen atmosphere. The catalyst was filtered off. From the filtrate, the solvent was distilled off to give the above-titled compound as colorless crystals (35 mg).

Workup

  1. filtrationThe catalyst was filtered off
  2. distillationFrom the filtrate, the solvent was distilled off

Sources & evidence

ORD record
ord-92703f3fb00944fa866eab531ae489fd
Source dataset
uspto-grants-1996_12
Patent number
US05585385

Reaction notes

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