Lactic Acid → Hydroxyacetic acid--2-hydroxypropanoic acid (1/1)

Participants

Reaction Conditions

Reaction Steps

A 1,000-ml four-necked flask equipped with a nitrogen inlet tube and a condenser was charged with 375.3 g of 90% lactic acid and 95.1 g of glycolic acid. The charge was heated in a nitrogen atmosphere under reduced pressure from 90° C. and 400 mmHg to 150° C. and 30 mmHg over 5 hours for removing the distillate water. Further heating under reduced pressure at 5-7 mmHg and 150°-175° C. for 24 hours followed by cooling gave an amber-colored lactic acid-glycolic acid copolymer.

Provenance & Evidence