Lactic Acid → Hydroxyacetic acid--2-hydroxypropanoic acid (1/1)

HRID 1081349Notes

Reaction equation

HRID 1081349 reaction equation
[C:1]([OH:6])(=[O:5])[CH:2]([CH3:4])[OH:3].[C:7]([OH:11])(=[O:10])[CH2:8][OH:9]>>[C:1]([OH:6])(=[O:5])[CH:2]([CH3:4])[OH:3].[C:7]([OH:11])(=[O:10])[CH2:8][OH:9]

Participants

3

Reactant 2

HCID 612Lactic AcidHCID 757Glycolic Acid

Product 1

HCID 36797Hydroxyacetic acid--2-hydroxypropanoic acid (1/1)

Conditions

Temperature
90 °C

Procedure

A 1,000-ml four-necked flask equipped with a nitrogen inlet tube and a condenser was charged with 375.3 g of 90% lactic acid and 95.1 g of glycolic acid. The charge was heated in a nitrogen atmosphere under reduced pressure from 90° C. and 400 mmHg to 150° C. and 30 mmHg over 5 hours for removing the distillate water. Further heating under reduced pressure at 5-7 mmHg and 150°-175° C. for 24 hours followed by cooling gave an amber-colored lactic acid-glycolic acid copolymer.

Workup

  1. customA 1,000-ml four-necked flask equipped with a nitrogen inlet tube and a condenser
  2. custom400 mmHg to 150° C. and 30 mmHg over 5 hours for removing the distillate water
  3. temperatureFurther heating under reduced pressure at 5-7 mmHg and 150°-175° C. for 24 hours
  4. temperatureby cooling

Sources & evidence

ORD record
ord-a3beb7dc551b4a1dbc51bd6a38b92930
Source dataset
uspto-grants-1996_12
Patent number
US05585460

Reaction notes

Loading…