反应详情

A suspension of 4.1 g (13.3 mmol) of ethyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate in 150 mL of 6N hydrochloric acid was refluxed for 6 hours, then cooled to room temperature. The solids were filtered, washed with water and ether, and dried to give 3.2 g of the title compound, mp>300° C.

1. temperaturewas refluxed for 6 hours
2. filtrationThe solids were filtered
3. washwashed with water and ether
4. customdried