Piperazine → HCID 14651175, compound

HRID 1081426Notes

Reaction equation

HRID 1081426 reaction equation
[Cl:1][C:2]1[C:3](F)=[C:4]([F:20])[C:5]([CH3:19])=[C:6]2[C:11]=1[N:10]([CH:12]1[CH2:14][CH2:13]1)[CH:9]=[C:8]([C:15]([OH:17])=[O:16])[C:7]2=[O:18].[NH:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>C(#N)C>[Cl:1][C:2]1[C:3]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)=[C:4]([F:20])[C:5]([CH3:19])=[C:6]2[C:11]=1[N:10]([CH:12]1[CH2:14][CH2:13]1)[CH:9]=[C:8]([C:15]([OH:17])=[O:16])[C:7]2=[O:18]

Participants

4

Reactant 2

HCID 4837PiperazineHCID 14651260HCID 14651260, compound

Product 1

HCID 14651175HCID 14651175, compoundYield 69.6%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A suspension of 0.38 g (1.21 mmol) of 8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-5-methyl-4-oxo-3-quinolinecarboxylic acid, 0.42 g (4.88 mmol) of piperazine and 20 mL of acetonitrile was refluxed for 4 hours, and then stirred at room temperature overnight. The precipitate was collected by filtration, washed with water and acetonitrile, and dried in vacuo to give 0.32 g of the title compound, mp 234°-235° C.

Workup

  1. temperaturewas refluxed for 4 hours
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water and acetonitrile
  4. customdried in vacuo

Sources & evidence

ORD record
ord-3be44476f25a4bd1b521170f8febf29c
Source dataset
uspto-grants-1996_12
Patent number
US05585491

Reaction notes

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