反应详情

A mixture of 40 g of 4-nitrophenol, 41 g of 1-bromo-2-methoxyethane, 45 g of K2CO3 and 80 ml of tris[2-(2-methoxyethoxy)ethyl]amine in 80 ml of acetone is refluxed for 20 hours. An insoluble material is filtered off and the filtrate is concentrated under vacuum. The residue is taken up with water and the precipitate formed is filtered off and washed with water. The precipitate is dissolved in AcOEt, washed with a 1N solution of NaOH, with water, with a 1N solution of HCl and with water and dried over Na2SO4 and the solvent is evaporated off under vacuum to give 59 g of the expected product, which is used as such in the next step.

1. temperatureis refluxed for 20 hours
2. filtrationAn insoluble material is filtered off
3. concentrationthe filtrate is concentrated under vacuum
4. customthe precipitate formed
5. filtrationis filtered off
6. washwashed with water
7. dissolutionThe precipitate is dissolved in AcOEt
8. washwashed with a 1N solution of NaOH, with water, with a 1N solution of HCl and with water
9. dry with materialdried over Na2SO4
10. customthe solvent is evaporated off under vacuum