Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Nitrophenol → 1-(2-Methoxyethoxy)-4-nitrobenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Nitrophenol | HCID 980 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Bromoethyl methyl ether | HCID 80972 | — |
| 반응물 | Ethanamine, 2-(2-methoxyethoxy)-N,N-bis[2-(2-methoxyethoxy)ethyl]- | HCID 112414 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 1-(2-Methoxyethoxy)-4-nitrobenzene | HCID 547809 | 104.1% |
반응 단계
A mixture of 40 g of 4-nitrophenol, 41 g of 1-bromo-2-methoxyethane, 45 g of K2CO3 and 80 ml of tris[2-(2-methoxyethoxy)ethyl]amine in 80 ml of acetone is refluxed for 20 hours. An insoluble material is filtered off and the filtrate is concentrated under vacuum. The residue is taken up with water and the precipitate formed is filtered off and washed with water. The precipitate is dissolved in AcOEt, washed with a 1N solution of NaOH, with water, with a 1N solution of HCl and with water and dried over Na2SO4 and the solvent is evaporated off under vacuum to give 59 g of the expected product, which is used as such in the next step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05585394 |
| 출처 데이터셋 | uspto-grants-1996_12 |
| ORD ID | ord-7ab42f32f6ca4f2e91fc1c0a5cbe14e0 |
| 출처 메모 | uspto-grants-1996_12 |