HCID 15229038, compound → HCID 15229040, compound

HRID 1081480Notes

Reaction equation

HRID 1081480 reaction equation
[Cl:1][C:2]1[CH:31]=[CH:30][C:5]2[N:6]([S:16]([C:19]3[CH:24]=[CH:23][C:22]([N+:25]([O-])=O)=[CH:21][C:20]=3[O:28][CH3:29])(=[O:18])=[O:17])[C:7](=[O:15])[N:8]([CH:9]3[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]3)[C:4]=2[CH:3]=1>[Ni].CCO>[Cl:1][C:2]1[CH:31]=[CH:30][C:5]2[N:6]([S:16]([C:19]3[CH:24]=[CH:23][C:22]([NH2:25])=[CH:21][C:20]=3[O:28][CH3:29])(=[O:18])=[O:17])[C:7](=[O:15])[N:8]([CH:9]3[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]3)[C:4]=2[CH:3]=1

Participants

4

Reactant 1

HCID 15229038HCID 15229038, compound

Product 1

HCID 15229040HCID 15229040, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

1.8 g (4.10- 3 mol) of the compound obtained in Example 3 in 95° EtOH were hydrogenated under 50 bar in the presence of Raney® nickel. The catalyst was filtered off on C elite® and rinsed with hot 95° EtOH and the filtrate was evaporated under vacuum to give 1.22 g of the expected product in the form of a white solid. The product crystallized from absolute ethanol. M.p.=211° C.

Workup

  1. customin 95°
  2. filtrationThe catalyst was filtered off on C elite®
  3. washrinsed with hot 95° EtOH
  4. customthe filtrate was evaporated under vacuum

Sources & evidence

ORD record
ord-cdfe329128e54c8d916f2e7156dc7afe
Source dataset
uspto-grants-1996_12
Patent number
US05585394

Reaction notes

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