Sodium Hydroxide → HCID 23362742, compound

HRID 1081558Notes

Reaction equation

HRID 1081558 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4](Cl)=O.[OH-].[Na+].O.[NH2:15][NH2:16]>O>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]1[N:15]=[N:16][C:4]([C:3]2[C:7]([F:11])=[CH:8][CH:9]=[CH:10][C:2]=2[F:1])=[N:15][N:16]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 24654Hydrazine hydrate (1:1)HCID 874382,6-Difluorobenzoyl chloride

Product 1

HCID 23362742HCID 23362742, compoundYield 164.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

9.05 g of 2,6-difluorobenzoyl chloride and a solution of 2.17 g of sodium hydroxide in 7.5 ml of water are simultaneously dropped into a solution of 1.25 g of hydrazine hydrate in 25 ml of water under stirring and cooling by ice-water. After addition, the white suspension is stirred at room temperature for 2 hours. After filtration the solid product is washed with water and recrystallized from glacial acetic acid to yield 6.3 g of desired product as white crystals.

Workup

  1. additionAfter addition
  2. stirringthe white suspension is stirred at room temperature for 2 hours
  3. filtrationAfter filtration the solid product
  4. washis washed with water
  5. customrecrystallized from glacial acetic acid

Sources & evidence

ORD record
ord-65683302d6e94f4987dd40ae4633fed5
Source dataset
uspto-grants-1996_12
Patent number
US05587370

Reaction notes

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