Sodium Hydroxide → HCID 23363018, compound

HRID 1081671Notes

Reaction equation

HRID 1081671 reaction equation
Cl.Cl[CH2:3][C:4]1[C:9]([CH3:10])=[C:8]([S:11][CH2:12][C:13]2[CH:17]=[CH:16][S:15][CH:14]=2)[CH:7]=[CH:6][N:5]=1.[SH:18][C:19]1[NH:23][C:22]2[CH:24]=[CH:25][CH:26]=[CH:27][C:21]=2[N:20]=1.[OH-].[Na+]>C(O)C>[CH3:10][C:9]1[C:4]([CH2:3][S:18][C:19]2[NH:23][C:22]3[CH:24]=[CH:25][CH:26]=[CH:27][C:21]=3[N:20]=2)=[N:5][CH:6]=[CH:7][C:8]=1[S:11][CH2:12][C:13]1[CH:17]=[CH:16][S:15][CH:14]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 23363016HCID 23363016, compoundHCID 178527775HCID 178527775, compound

Product 1

HCID 23363018HCID 23363018, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Chloromethyl-3-methyl-4-(3-thienylmethylthio)pyridine hydrochloride, 2-mercapto-1H-benzimidazole and sodium hydroxide are reacted in ethanol at 25° C. for 20 h. After crystallization from toluene/methanol, the title compound is isolated. Yield: 62%, m.p. 161°-164° C.

Workup

  1. customAfter crystallization from toluene/methanol

Sources & evidence

ORD record
ord-7634a6b2616f41a6b59981db3b1ebeb6
Source dataset
uspto-grants-1996_12
Patent number
US05587389

Reaction notes

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