Sodium Hydroxide → HCID 23363024, compound

HRID 1081672Notes

Reaction equation

HRID 1081672 reaction equation
Cl.Cl[CH2:3][C:4]1[C:9]([O:10][CH3:11])=[C:8]([S:12][CH2:13][C:14]2[S:15][CH:16]=[CH:17][CH:18]=2)[CH:7]=[CH:6][N:5]=1.[SH:19][C:20]1[NH:24][C:23]2[CH:25]=[CH:26][CH:27]=[CH:28][C:22]=2[N:21]=1.[OH-].[Na+]>C(O)C>[CH3:11][O:10][C:9]1[C:4]([CH2:3][S:19][C:20]2[NH:24][C:23]3[CH:25]=[CH:26][CH:27]=[CH:28][C:22]=3[N:21]=2)=[N:5][CH:6]=[CH:7][C:8]=1[S:12][CH2:13][C:14]1[S:15][CH:16]=[CH:17][CH:18]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 23363017HCID 23363017, compoundHCID 178527775HCID 178527775, compound

Product 1

HCID 23363024HCID 23363024, compoundYield 56%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Chloromethyl-3-methoxy-4-(2-thienylmethylthio)pyridine hydrochloride, 2-mercapto-1H-benzimidazole and sodium hydroxide are reacted in ethanol at 25° C. for 20 h. After crystallization from toluene/methanol, the title compound is isolated. Yield: 56%, m.p. 124°-127° C. 8. 2-{[[4-(2-Thienylmethylthio)-2,pyridinyl]methyl]thio}-1H-benzimidazole

Workup

  1. customAfter crystallization from toluene/methanol

Sources & evidence

ORD record
ord-07d74879ea694231bb08df86b7550fad
Source dataset
uspto-grants-1996_12
Patent number
US05587389

Reaction notes

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