Sodium Hydroxide → HCID 178488133, compound

HRID 1081675Notes

Reaction equation

HRID 1081675 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]2[NH:7][C:8]([SH:10])=[N:9][C:5]=2[CH:4]=1.Cl.Cl[CH2:15][C:16]1[C:21]([CH3:22])=[C:20]([S:23][CH2:24][CH2:25][C:26]2[S:30][CH:29]=[N:28][C:27]=2[CH3:31])[CH:19]=[CH:18][N:17]=1.[OH-].[Na+]>>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]2[NH:7][C:8]([S:10][CH2:15][C:16]3[C:21]([CH3:22])=[C:20]([S:23][CH2:24][CH2:25][C:26]4[S:30][CH:29]=[N:28][C:27]=4[CH3:31])[CH:19]=[CH:18][N:17]=3)=[N:9][C:5]=2[CH:4]=1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 221173062-Chloromethyl-3-methyl-4-[2-(4-methyl-5-thiazolyl)ethylthio]pyridine hydrochlorideHCID 178488140HCID 178488140, compound

Product 1

HCID 178488133HCID 178488133, compound

Procedure

Following the procedure described in Example 1, the reaction of 5-methoxy-2-mercapto-1H-benzimidazole with 2-chloromethyl-3-methyl-4-[2-(4-methyl-5-thiazolyl)ethylthio]pyridine hydrochloride and aqueous sodium hydroxide solution gives the title compound as a yellow oil, from which a hydrochloride salt of the title compound is obtained as a colorless powder of m.p. 165° C (decomp.) by following the procedure described in Example 4.

Sources & evidence

ORD record
ord-190f2e7e02504de8a5d1ed18c0edcf62
Source dataset
uspto-grants-1996_12
Patent number
US05587389

Reaction notes

Loading…