2-Chloromethyl-4-(2-furylmethylthio)-3-methylpyridine hydrochloride → 2,2-Difluoro-6-{[[4-(2-furylmethylthio)-3-methyl-2-pyridinyl]methyl]thio}-5H-[1,3]dioxolo-[4,5-f]benzimidazole dihydrochloride

HRID 1081679Notes

Reaction equation

HRID 1081679 reaction equation
[ClH:1].[Cl:2][CH2:3][C:4]1[C:9]([CH3:10])=[C:8]([S:11][CH2:12][C:13]2[O:14][CH:15]=[CH:16][CH:17]=2)[CH:7]=[CH:6][N:5]=1.[F:18][C:19]1([F:32])[O:31][C:22]2=[CH:23][C:24]3[NH:28][C:27]([SH:29])=[N:26][C:25]=3[CH:30]=[C:21]2[O:20]1>C(O)(C)C>[ClH:2].[ClH:1].[F:32][C:19]1([F:18])[O:31][C:22]2=[CH:23][C:24]3[NH:28][C:27]([S:29][CH2:3][C:4]4[C:9]([CH3:10])=[C:8]([S:11][CH2:12][C:13]5[O:14][CH:15]=[CH:16][CH:17]=5)[CH:7]=[CH:6][N:5]=4)=[N:26][C:25]=3[CH:30]=[C:21]2[O:20]1

Participants

4

Reactant 2

HCID 224607712-Chloromethyl-4-(2-furylmethylthio)-3-methylpyridine hydrochlorideHCID 178506005HCID 178506005, compound

Product 1

HCID 233630202,2-Difluoro-6-{[[4-(2-furylmethylthio)-3-methyl-2-pyridinyl]methyl]thio}-5H-[1,3]dioxolo-[4,5-f]benzimidazole dihydrochloride

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Following the procedure described in Example 12, the reaction of 2-chloromethyl-4-(2-furylmethylthio)-3-methylpyridine hydrochloride with 2,2-difluoro-6-mercapto-5H-[1,3]dioxolo-[4,5-f]benzimidazole in isopropanol gives the title compound as a colorless solid; m.p. 180-183° C. (decomp.).

Sources & evidence

ORD record
ord-87d0b7b2e650490697526428fbd9d783
Source dataset
uspto-grants-1996_12
Patent number
US05587389

Reaction notes

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