Sodium Thiosulfate → 2-{[[4-(2-Furylmethylthio)-3-methyl-2-pyridinyl]methyl]sulfinyl}-1H-benzimidazole

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Reaction Steps

2-{[[4-(2-Furylmethylthio)-3-methyl-2-pyridinyl]methyl]thio}-1H-benzimidazole (2 mmol) are dissolved in 15 ml of dioxane + NaOH (6 mmol; 2N), and the solution is treated with 2.5 mmol of 7 percent strength sodium hypochlorite solution at 20° C. Sodium thiosulfate is added, dioxane is distilled off, the pH is brought to 9, the mixture is extracted using dichloromethane, and the product is crystallized from dichloromethane/diisopropyl ether. This gives the title compound (yield 80%) of m.p. 173° C. (decomp.) as a colorless solid.

Provenance & Evidence