反应详情

2-{[[4-(2-Furylmethylthio)-3-methyl-2-pyridinyl]methyl]thio}-1H-benzimidazole (2 mmol) are dissolved in 15 ml of dioxane + NaOH (6 mmol; 2N), and the solution is treated with 2.5 mmol of 7 percent strength sodium hypochlorite solution at 20° C. Sodium thiosulfate is added, dioxane is distilled off, the pH is brought to 9, the mixture is extracted using dichloromethane, and the product is crystallized from dichloromethane/diisopropyl ether. This gives the title compound (yield 80%) of m.p. 173° C. (decomp.) as a colorless solid.

1. distillationdioxane is distilled off
2. extractionthe mixture is extracted
3. customthe product is crystallized from dichloromethane/diisopropyl ether