Acetone → 2,5-Difluoroanisole

HRID 1081937Notes

Reaction equation

HRID 1081937 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[OH:9].[CH3:10]C(C)=O.C(=O)([O-])[O-].[K+].[K+].S(OC)(OC)(=O)=O>O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[O:9][CH3:10]

Participants

6

Reactant 4

HCID 180AcetoneHCID 6497Dimethyl SulfateHCID 11430Potassium CarbonateHCID 949522,5-Difluorophenol

Product 1

HCID 27249892,5-Difluoroanisole

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

35.0 g of the product of Step A, 350 ml of acetone, 44.6 g of potassium carbonate and 40.7 g of dimethyl sulfate (neutralized on potassium bicarbonte) and was allowed to returnto ambient temperature. Water was added and extraction was carried out with ether. The extracts were washed, dried and concentrated to dryness under reduced pressure to obtain 39.8 g of the desired product.

Workup

  1. customto returnto ambient temperature
  2. extractionextraction
  3. washThe extracts were washed
  4. customdried
  5. concentrationconcentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-119a67992fbe4cbe9939be9246da97a8
Source dataset
uspto-grants-1996_12
Patent number
US05587372

Reaction notes

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