Dichloromethane → 2-oxoethyl Benzoate

HRID 1081955Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1081955
[C:1]([O:9][CH2:10][CH:11](CO)[OH:12])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(Cl)Cl.[O-]S([O-])(=O)=O.[Mg+2]>O>[C:1]([O:9][CH2:10][CH:11]=[O:12])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 6344DichloromethaneHCID 24083Sulfuric acid magnesium salt (1:1)HCID 1379111-Monobenzoylglycerol

Produkt 1

HCID 108666642-oxoethyl BenzoateAusbeute 62,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

This known intermediate was prepared by portionwise addition of NaIO4 (80 g) to a mixture of 1-benzoyl glycerol (50 g), CH2Cl2 (500 ml), and H2O (25 ml) under vigorous stirring at room temperature. The resulting solution was stirred for 2 hours, MgSO4 (100 g) was added and the solution stirred for an additional 30 minutes. The mixture was filtered, the filtrate evaporated in vacuo and the residue distilled in vacuo to yield 26 g of pure product.

Aufarbeitung

  1. stirringThe resulting solution was stirred for 2 hours
  2. stirringthe solution stirred for an additional 30 minutes
  3. filtrationThe mixture was filtered
  4. customthe filtrate evaporated in vacuo
  5. distillationthe residue distilled in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-17fc59faa1f34373b84e39d0c764f8b4
Quelldatensatz
uspto-grants-1996_12
Patentnummer
US05587480

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