Cyanamide → {4-Amino-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-thiazol-5-yl}-(3-difluoromethoxy-phenyl)-methanone

HRID 10820Notes

Reaction equation

HRID 10820 reaction equation
[N:1]#[C:2][NH2:3].[N:4]([C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH2:18][CH2:17][N:16]([CH3:19])[CH2:15][CH2:14]2)=[CH:9][CH:8]=1)=[C:5]=[S:6].Br[CH2:21][C:22]([C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH:31]([F:33])[F:32])[CH:25]=1)=[O:23]>>[NH2:1][C:2]1[N:3]=[C:5]([NH:4][C:7]2[CH:8]=[CH:9][C:10]([N:13]3[CH2:14][CH2:15][N:16]([CH3:19])[CH2:17][CH2:18]3)=[CH:11][CH:12]=2)[S:6][C:21]=1[C:22]([C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH:31]([F:32])[F:33])[CH:25]=1)=[O:23]

Participants

4

Reactant 3

HCID 9864CyanamideHCID 27782662-Bromo-1-(3-(difluoromethoxy)phenyl)ethan-1-oneHCID 137183971-(4-Isothiocyanatophenyl)-4-methylpiperazine

Product 1

HCID 21958903{4-Amino-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-thiazol-5-yl}-(3-difluoromethoxy-phenyl)-methanone

Procedure

This compound was prepared from cyanamide, 1-(4-isothiocyanatophenyl)-4-methylpiperazine (of Example 1) and 2-bromo-1-(3-difluoromethoxy-phenyl)ethanone (of Example 14L) following the procedure used in Example 24. Mass spectrum (ES) MH+=460.

Sources & evidence

ORD record
ord-3cb452d5092d4ae89fecc9ecd25459f7
Source dataset
uspto-grants-2006_08
Patent number
US07094896B2

Reaction notes

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