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Cyanamide → {4-Amino-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-thiazol-5-yl}-(3-difluoromethoxy-phenyl)-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyanamide | HCID 9864 | — |
| 反応物 | 2-Bromo-1-(3-(difluoromethoxy)phenyl)ethan-1-one | HCID 2778266 | — |
| 反応物 | 1-(4-Isothiocyanatophenyl)-4-methylpiperazine | HCID 13718397 | — |
| 生成物 | {4-Amino-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-thiazol-5-yl}-(3-difluoromethoxy-phenyl)-methanone | HCID 21958903 | — |
反応手順
This compound was prepared from cyanamide, 1-(4-isothiocyanatophenyl)-4-methylpiperazine (of Example 1) and 2-bromo-1-(3-difluoromethoxy-phenyl)ethanone (of Example 14L) following the procedure used in Example 24. Mass spectrum (ES) MH+=460.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07094896B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-3cb452d5092d4ae89fecc9ecd25459f7 |
| 出典メモ | uspto-grants-2006_08 |