HCID 53936852, compound → HCID 54097674, compound

HRID 1082161Notes

Reaction equation

HRID 1082161 reaction equation
[CH3:1][O:2][C:3](=[O:23])[C:4]1[C:9]([Br:10])=[C:8]([O:11][CH3:12])[CH:7]=[C:6]([O:13][Si:14]([C:17]([CH3:20])([CH3:19])[CH3:18])([CH3:16])[CH3:15])[C:5]=1[CH2:21]Br.[SH:24][CH2:25][C@H:26]([NH:33][C:34](=[O:36])[CH3:35])[C:27]1[O:31][N:30]=[C:29]([CH3:32])[N:28]=1>>[CH3:1][O:2][C:3](=[O:23])[C:4]1[C:9]([Br:10])=[C:8]([O:11][CH3:12])[CH:7]=[C:6]([O:13][Si:14]([C:17]([CH3:20])([CH3:19])[CH3:18])([CH3:16])[CH3:15])[C:5]=1[CH2:21][S:24][CH2:25][C@H:26]([NH:33][C:34](=[O:36])[CH3:35])[C:27]1[O:31][N:30]=[C:29]([CH3:32])[N:28]=1

Participants

3

Reactant 2

HCID 53936852HCID 53936852, compoundHCID 54129522HCID 54129522, compound

Product 1

HCID 54097674HCID 54097674, compound

Procedure

6-Bromo-2-bromomethyl-3-(tert-butyl -dimethylsilanyloxy)-5-methoxy-benzoic acid methyl ester and (R)-N-[2-mercapto-1-(3-methyl-1,2,4-oxadiazol-5-yl)-ethyl]-acetamide were subjected in an analogous manner to the procedure described in Example 6(b) to yield (R)-2-[2-acetylamino-2-(3-methyl-1,2,4-oxadiazol-5-yl)-ethylsulfanylmethyl]-6-bromo-3-(tert-butyl-dimethyl-silanyloxy)-5-methoxybenzoic acid methyl ester as a pale yellow oil.

Sources & evidence

ORD record
ord-d6f3fab1975e4d88bbe14bdbf92a9131
Source dataset
uspto-grants-1996_12
Patent number
US05589473

Reaction notes

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