Methyl chloroacetate → HCID 13336496, compound

HRID 1084303Notes

Reaction equation

HRID 1084303 reaction equation
Cl[CH2:2]C(OC)=O.[CH2:7]([C:9]1([C:18]([C:20]2[CH:31]=[CH:30][C:23]([O:24][CH2:25][C:26]([O:28]C)=O)=[CH:22][CH:21]=2)=[O:19])[CH2:13][C:12]2[CH:14]=[CH:15][CH:16]=[CH:17]C=2O1)[CH3:8].[OH2:32].[NH3:33]>>[CH2:8]([C:7]1[O:32][C:17]2[CH:16]=[CH:15][CH:14]=[CH:12][C:13]=2[C:9]=1[C:18]([C:20]1[CH:21]=[CH:22][C:23]([O:24][CH2:25][C:26]([NH2:33])=[O:28])=[CH:30][CH:31]=1)=[O:19])[CH3:2]

Participants

4

Reactant 3

HCID 7295Methyl chloroacetateHCID 12896473Azane;hydrateHCID 67926483HCID 67926483, compound2×

Product 1

HCID 13336496HCID 13336496, compound

Procedure

According to the Procedure B of Example 1, the intermediate of the Example 3 was reacted with methyl chloroacetate. The resulting product methyl 4-(2ethyl-benzofuroyl)phenoxyacetate (Compound 11) was treated with concentrated ammonia water (28%) 100 ml and was stirred under ice-cooled condition for three hours. The white powder thus obtained, after drying was recrystallized from methanol.

Workup

  1. temperaturecooled condition for three hours
  2. customThe white powder thus obtained
  3. customafter drying
  4. customwas recrystallized from methanol

Sources & evidence

ORD record
ord-1da61f8d497e41688548bf2f2ecbabed
Source dataset
uspto-grants-1991_04
Patent number
US05004750

Reaction notes

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