Ammonia → HCID 18960789, compound

HRID 1084330Notes

Reaction equation

HRID 1084330 reaction equation
Br[C:2]1[C:3]([C:11]([OH:13])=[O:12])=[CH:4][C:5]([C:8]([OH:10])=[O:9])=[N:6][CH:7]=1.[NH3:14]>S([O-])([O-])(=O)=O.[Cu+2]>[NH2:14][C:2]1[C:3]([C:11]([OH:13])=[O:12])=[CH:4][C:5]([C:8]([OH:10])=[O:9])=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 14256373HCID 14256373, compound

Product 1

HCID 18960789HCID 18960789, compound

Reagents, catalysts & solvents 1

HCID 24462Copper SulfateCatalyst

Conditions

Temperature
160 °C

Procedure

A mixture of 500 mg of 5-bromo-pyridine-2,4-dicarboxylic acid from Example 2, 100 mg of copper sulfate and 20 ml of ammonia solution (d=0.91) is heated at 160° C. in an autoclave for 4 hours. The solution is evaporated to dryness, the solid is heated with a little methanol and the insoluble material is removed from the solution. After 20 hours, a white solid precipitates out at 0° C. and is filtered off and dried.

Workup

  1. customThe solution is evaporated to dryness
  2. temperaturethe solid is heated with a little methanol
  3. customthe insoluble material is removed from the solution
  4. customa white solid precipitates out at 0° C.
  5. filtrationis filtered off
  6. customdried

Sources & evidence

ORD record
ord-40334f8fff874de1804d943a41794fba
Source dataset
uspto-grants-1991_04
Patent number
US05004748

Reaction notes

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