1-Ethylpiperazine → HCID 14700562, compound

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Reaction Steps

8-(4-Ethyl-1-piperazinyl)-7-fluoro-1-methyl-4-oxo-1,4-dihydro=benzo[b][1,8]naphthyridine-3-carboxylic acid is prepared under the conditions described below in Example 5 but starting from 1.85 g of 8-chloro-7-fluoro-1-methyl-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine-3-carboxylic acid and 2.75 g of 1-ethylpiperazine in 20 cm3 of pyridine. 1.3 g of 8-(4-ethyl-1-piperazinyl)-7-fluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid are obtained in the form of a yellow solid melting at 285°-286° C.

Provenance & Evidence