1-Ethylpiperazine → HCID 14700562, compound

HRID 1084359Notes

Reaction equation

HRID 1084359 reaction equation
Cl[C:2]1[C:3]([F:21])=[CH:4][C:5]2[C:6]([CH:20]=1)=[N:7][C:8]1[N:9]([CH3:19])[CH:10]=[C:11]([C:16]([OH:18])=[O:17])[C:12](=[O:15])[C:13]=1[CH:14]=2.[CH2:22]([N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1)[CH3:23]>N1C=CC=CC=1>[N:9]1[C:8]2[N:7]=[C:6]3[CH:20]=[CH:2][CH:3]=[CH:4][C:5]3=[CH:14][C:13]=2[CH:12]=[C:11]([C:16]([OH:18])=[O:17])[CH:10]=1.[CH2:22]([N:24]1[CH2:29][CH2:28][N:27]([C:2]2[C:3]([F:21])=[CH:4][C:5]3[C:6]([CH:20]=2)=[N:7][C:8]2[N:9]([CH3:19])[CH:10]=[C:11]([C:16]([OH:18])=[O:17])[C:12](=[O:15])[C:13]=2[CH:14]=3)[CH2:26][CH2:25]1)[CH3:23]

Participants

5

Reactant 2

HCID 791961-EthylpiperazineHCID 147005548-Chloro-7-fluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid

Product 2

HCID 14700562HCID 14700562, compoundYield 112.1%HCID 53771869HCID 53771869, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

8-(4-Ethyl-1-piperazinyl)-7-fluoro-1-methyl-4-oxo-1,4-dihydro=benzo[b][1,8]naphthyridine-3-carboxylic acid is prepared under the conditions described below in Example 5 but starting from 1.85 g of 8-chloro-7-fluoro-1-methyl-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine-3-carboxylic acid and 2.75 g of 1-ethylpiperazine in 20 cm3 of pyridine. 1.3 g of 8-(4-ethyl-1-piperazinyl)-7-fluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid are obtained in the form of a yellow solid melting at 285°-286° C.

Sources & evidence

ORD record
ord-011c5854ed4642d68ae34ea65517b0b1
Source dataset
uspto-grants-1991_04
Patent number
US05004745

Reaction notes

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