Hydrochloric Acid → 2-(3,5-dichlorophenyl)propan-2-amine

HRID 1084629Notes

Reaction equation

HRID 1084629 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:11]=[C:12]([Cl:14])[CH:13]=1)[C:5]([NH:8]C=O)([CH3:7])[CH3:6].Cl.[OH-].[Na+]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:11]=[C:12]([Cl:14])[CH:13]=1)[C:5]([NH2:8])([CH3:6])[CH3:7]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 15754135N-(3,5-dichloroalpha,alpha-dimethylbenzyl)formamide

Product 1

HCID 111950522-(3,5-dichlorophenyl)propan-2-amineYield 98%

Procedure

A mixture of 1.16 g (5 mmol) of N-(3,5-dichloro,α,α-dimethylbenzyl)formamide and 8 ml of 2N hydrochloric acid was refluxed for 30 minute. After cooling, the reaction solution was alkalified with a sodium hydroxide aqueous solution and extracted with diethyl ether. The ether solution was washed with water, dried and then concentrated to obtain 1.0 g (yield: 98.0%) of the desired compound.

Workup

  1. temperaturewas refluxed for 30 minute
  2. temperatureAfter cooling
  3. extractionextracted with diethyl ether
  4. washThe ether solution was washed with water
  5. customdried
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-a0374ac6c9b247f4ba249b9919659d8e
Source dataset
uspto-grants-1991_04
Patent number
US05006157

Reaction notes

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