反应详情

A mixture of 1.16 g (5 mmol) of N-(3,5-dichloro,α,α-dimethylbenzyl)formamide and 8 ml of 2N hydrochloric acid was refluxed for 30 minute. After cooling, the reaction solution was alkalified with a sodium hydroxide aqueous solution and extracted with diethyl ether. The ether solution was washed with water, dried and then concentrated to obtain 1.0 g (yield: 98.0%) of the desired compound.

1. temperaturewas refluxed for 30 minute
2. temperatureAfter cooling
3. extractionextracted with diethyl ether
4. washThe ether solution was washed with water
5. customdried
6. concentrationconcentrated