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HRID1084722

反应详情

EQUATION

反应方程式

HRID 1084722 的结构方程式

REACTANTS

反应物

2
结构：CC(=O)N1CCC2(CC1)NC1=CC=CCC1=C1N=c3ccccc3=C12
HCID19824920

未命名化合物

结构：C1CCOC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]
HCID68718528

未命名化合物

PRODUCTS

生成物

1
结构：CCN1CCC2(CC1)NC1=CC=CCC1=C1N=c3ccccc3=C12
HCID19824921

未命名化合物

收率 48.7%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

结构：CO.ClCCl
溶剂HCID21226129

未命名化合物

PROCEDURE

实验过程

A solution of 7.5 g of 1'-acetyl-5,6-dihydrospiro-[1H-indolo-[3,2-c]quinoline-6,4'-piperidine] in 60 ml of THF was added dropwise to 45 ml of 1M LiAlH4 /THF. The solution was stirred at room temperature for 30 minutes and thereafter quenched with NH4Cl, filtered through celite and concentrated to give 9.2 g of crude product. Flash chromatography using 7% CH3OH/CH2Cl2 as an eluent gave 3.5 g of solid, m.p. 238°-240° dec.

WORKUP

后处理

  1. customquenched with NH4Cl
  2. filtrationfiltered through celite and
  3. concentrationconcentrated
  4. customto give 9.2 g of crude product