Ethyl Acetate → HCID 21620084, compound

HRID 1084787Notes

Reaction equation

HRID 1084787 reaction equation
[N:1]1([CH2:6][C:7](C2C=CC(C#N)=CC=2)=[CH:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[CH:5]=[N:4][CH:3]=[N:2]1.[H][H].C(O[CH2:33][CH3:34])(=O)C>[Pd]>[N:1]1([CH2:6][CH:7]([C:34]2[CH:33]=[CH:10][CH:9]=[CH:8][C:7]=2[C:6]#[N:1])[CH2:8][C:9]2[CH:10]=[CH:11][C:12]([C:15]([F:16])([F:17])[F:18])=[CH:13][CH:14]=2)[CH:5]=[N:4][CH:3]=[N:2]1

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 54450097HCID 54450097, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21620084HCID 21620084, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A mixture of 4-[1-(1,2,4-triazol-1-ylmethyl)-2-(4-trifluoromethylphenyl)vinyl]benzonitrile (0.05 g, mixed E and Z isomers) and 10% by weight palladium-on-carbon (0.02 g) in ethyl acetate (5 ml) was stirred rapidly under an atomosphere of hydrogen at atmospheric pressure for 2h. The mixture was filtered, and the filtrate was evaporated to dryness, to give 4-([2-(1,2,4-triazol-1-yl)-1-(4-trifluoromethylbenzyl)ethyl]benzonitrile as a white solid, which was washed with ethyl acetate and dried, m.p. 123°.

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated to dryness

Sources & evidence

ORD record
ord-13bd1ddd07dc4b059f8e0019297bb097
Source dataset
uspto-grants-1991_04
Patent number
US05006543

Reaction notes

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