Potassium Hydroxide → HCID 18644906, compound

HRID 1084809Notes

Reaction equation

HRID 1084809 reaction equation
[OH-].[K+].[S:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[O:13])[CH2:5][CH2:4]1.[CH3:14][C:15]1[N:19]([C:20]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:18]=[N:17][C:16]=1[CH:39]=O>CO>[CH3:14][C:15]1[N:19]([C:20]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:18]=[N:17][C:16]=1/[CH:39]=[C:5]1/[CH2:4][S:3][C:12]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[C:6]/1=[O:13]

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 19048Thiochroman-4-oneHCID 118243385-methyl-1-trityl-1H-imidazole-4-carbaldehyde

Product 1

HCID 18644906HCID 18644906, compoundYield 74.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A solution of potassium hydroxide (0.5 g) in methanol (5 ml) was added to a solution of thiochroman-4-one (0.93 g) and 5-methyl-1-(triphenylmethyl)-1H-imidazole-4-carboxaldehyde (2 g) in methanol (25 ml), and the resulting solution was stirred at 50° for 3.5 h. The resultant precipitate was filtered off, washed with methanol (20 ml) and dried to give the title compound (2.1 g), m.p. 225°-226°.

Workup

  1. filtrationThe resultant precipitate was filtered off
  2. washwashed with methanol (20 ml)
  3. customdried

Sources & evidence

ORD record
ord-64a2b11ac26044ac8875bbf6d441d6e3
Source dataset
uspto-grants-1991_04
Patent number
US05006544

Reaction notes

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