Methylhydrazine → HCID 86744718, compound

HRID 1084842Notes

Reaction equation

Cl[C:2]1[C:7]([C:8](=O)[C:9]2[CH:14]=[CH:13][C:12]([NH:15][CH2:16][CH2:17][N:18]([CH3:20])[CH3:19])=[CH:11][CH:10]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:22][NH:23][NH2:24].[C:25]([O-:32])(=[O:31])/[CH:26]=[CH:27]\[C:28]([O-:30])=[O:29]>>[CH3:22][N:23]1[C:2]2=[N:3][CH:4]=[CH:5][CH:6]=[C:7]2[C:8]([C:9]2[CH:14]=[CH:13][C:12]([NH:15][CH2:16][CH2:17][N:18]([CH3:20])[CH3:19])=[CH:11][CH:10]=2)=[N:24]1.[C:25]([O-:32])(=[O:31])/[CH:26]=[CH:27]\[C:28]([O-:30])=[O:29]

Participants

Reactant 3

HCID 6061Methylhydrazine

HCID 5288227Maleate(2-)

HCID 15158086HCID 15158086, compound

Product 1

HCID 86744718HCID 86744718, compound

Procedure

By conducting reactions and treatments in the same manner as in Example 42, using 5.8 g of 2-chloro-3-[4-(2-dimethylaminoethylamino)benzoyl]pyridine and 1.2 g of methylhydrazine, converting into the maleate and recrystallizing from ethyl acetate, there was obtained 1-methyl-3-[4-(2-dimethylaminoethylamino)phenyl]-1H-pyrazolo[3,4-b]pyridine·maleate, m.p. 88°-90° C.

Workup

customrecrystallizing from ethyl acetate

Sources & evidence

ORD record: ord-4de5f8173d42477aa617ac5b9eeb5802
Source dataset: uspto-grants-1991_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05006520

Reaction notes

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