Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 13983503 | HCID 13983503 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 13690889 | HCID 13690889 | — |
Reaction Steps
108 g of a 40% aqueous solution of methylamine and 108 ml of water were added into a 2-liter round-bottomed flask. The contents were cooled to 5° C. and 193 g of 5-chlorosulphonyl-2-methyl-2,3-dihydrobenzofuran-7-carboxylic acid were then added in portions of 10 g, while cooling in an ice and salt bath so as to maintain the temperature at 5° C. After each addition of acid, 14.5 ml of a solution containing 140 ml of 30% sodium hydroxide in 140 ml of water were added.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05006570 |
|---|
| Source dataset | uspto-grants-1991_04 |
|---|
| ORD ID | ord-b728dca0f87544b099b0a4820d1f2ea1 |
|---|
| Source note | uspto-grants-1991_04 |
|---|
